REN and Hypertension: Our data showed, in the kidney cortex, an upregulation of the mRNA of AT1R receptor in DOCA-treated rats, as previously described by Oishi et al.,28 and other kinds of perinatally programmed hypertension (such as a low protein diet)40,41, presumably reflecting the upregulated state of the receptors in the model, in which renin and ANG II are suppressed.