TGFBR1 and non-small cell lung carcinoma: To illustrate, in non-small cell lung cancer, METTL3-mediated m6A modification could enhance the stability of methylated lncRNA-RMRP transcripts, which further promotes TGFBR1 transcription and the activation of TGFBR1/SMAD2/SMAD3 signaling pathway [39].