In the current study, we found that m6A “writer” methyltransferase-like 3 (METTL3) plays important roles in corneal endothelial-mesenchymal transition (cEndMT) process and Fuchs endothelial corneal dystrophy (FECD) development (shown in Graphical Abstract). This evidence concerns the gene METTL3 and Fuchs endothelial corneal dystrophy.