AIF1 and glomerulosclerosis: Furthermore, the characteristic CKD features were evident, including interstitial fibrosis (Fig. 2c, e, j, Supplementary Fig. 4b), partial tubular atrophy (Supplementary Fig. 4c), glomerular sclerosis (Fig. 2e), and infiltration of Ionized calcium binding adapter molecule 1 (IBA1)+ macrophages (Fig. 2f).