Both subsets are highly proinflammatory and express various inflammatory cytokines and mediators such as Il4, Il5, Il13, Tnfsf11, Areg, Tgfb1, Calca and Furin, all of which are implicated in promoting allergic asthma and other allergic diseases1,79–84. The gene discussed is TNFSF11; the disease is allergic asthma.