To this end, we assessed whether post stroke rehabilitation induces activity-dependent gene expression and plasticity changes in the PV/stroke-projecting neuron circuit in RFA by the detection of immediate early genes Zif268 and FosB, and of perineuronal nets, a determinant of PV neuron plasticity50 (Supplementary Fig. 11a, g). The gene discussed is FOSB; the disease is Stroke.