In this regard, miR-221/222 inhibition has been highlighted to be essential for the maintenance of leukemic cell quiescence in adult acute and chronic lymphocytic leukemia [41, 42], while in vitro lentivirus-mediated restoration of miR-221/222 resulted in p27Kip1 targeting and cell-cycle progression, increased sensitivity to cytarabine and vincristine, and reduced relapse risk in adult acute lymphoblastic leukemia [43]. The gene discussed is CDKN1B; the disease is B-cell chronic lymphocytic leukemia.