At first glance, the documented here downregulation of miR-221/222 cluster in R-ISS III patients, as well as the association of miR-221/222 loss with worse treatment outcome of the patients contradicts the abovementioned functional role of miR-221/222 cluster in fostering the expression of p27Kip1/p57Kip2 CDKIs and reducing cell-cycle/proliferation of MM plasma cells. Here, CDKN1B is linked to Miyoshi myopathy.