These include results published previously on a BRCA1 breast and ovarian cancer predisposition variant that is 470-fold more common in Orkney than in the UKB,11 a KCNH2 long QT syndrome variant that is ∼90-fold more common in Shetland,10 and a P BRCA2 variant ∼155-fold more common in Shetland.12 This evidence concerns the gene BRCA1 and ovarian cancer.