Detailed analysis of PAR1 in HPSCs subsets of MPN patients showed that the relative PAR1 expression was increased in EMP (p = 0.0008), HSC/EPC (p = 0.0002) and EPCs (p = 0.0064) of MPN patients compared to CB (Fig.1B, D and E respectively). Here, F2R is linked to myeloproliferative neoplasm.