TMEM11 and Autoimmunity: To check the physiological role of TMEM11 in T cells, we used an animal model of autoimmunity, experimental autoimmune encephalitis (EAE), in which both Th1 and Th17 cells are important for the onset and pathogenicity of the disease.25 Active EAE-induced Tmem11−/− mice showed significant amelioration of clinical symptoms when compared to littermate controls (Figure S5A).