To demonstrate the regulatory role of YBX1 in ferroptosis in HCC, we used three different si‐RNAs targeting YBX1 and found that they significantly increased the production of lipid reactive oxygen species (ROS) and facilitated the dissipation of mitochondrial membrane potential (Figures 2A, B and S2A–C). Here, YBX1 is linked to hepatocellular carcinoma.