In addition, YBX1 bound to the m5C modification sites of RNF115 3′‐untranslated region (UTR) and interacted with Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) to bridge the 5′‐UTR regions, promoting mRNA circularisation and translation, while NOP2/Sun RNA methyltransferase 2 (NSUN2) was identified as responsible for m5C modification of RNF115 mRNA in HCC. The gene discussed is EIF4A1; the disease is hepatocellular carcinoma.