Our research findings demonstrate that IGF2BPs regulate post-transcriptional modifications by recognizing and binding to m6A-modified mRNA, participating in biological processes such as cell cycle changes, cell proliferation and division, DNA/RNA replication, transcription, translation and metabolism, DNA damage repair, and the activation of EMT and related pro-tumor signaling pathways such as AMPK, Hippo, PI3K-Akt, and p53. The gene discussed is TP53; the disease is neoplasm.