group, rats of DM + PD group, demonstrated markedly lower blood insulin (μIU/ml) and HDL (mg/dl) levels (P < 0.05) along with a significant increase (P < 0.05) in serum glucose (mg/dl), HBA1C (%), HOMA-IR, total cholesterol (mg/dl), LDL (mg/dl), and TG (mg/dl) levels. This evidence concerns the gene INS and Parkinson disease.