Further, dimensional reduction of CACNA2D2‐associated CpG sites in 24 DSRCT patient samples, compared with 192 samples from 13 morphological mimics [10] revealed distinct clustering of all DSRCT samples, which was unique to CACNA2D2 compared to other described EWSR1::WT1‐regulated genes or IQCG (Figure 1A, Supplementary Figures S4A‐B). Here, WT1 is linked to desmoplastic small round cell tumor.