Given the species differences and the numerous limitations of the Mct8‐deficient mouse model, which does not resemble the human phenotype of patients, we would suggest the use of human iPSC‐derived dopaminergic midbrain neurons expressing MCT844 as a future in vitro experimental system to address these important questions of the pathogenesis of parkinsonism in AHDS.45 This evidence concerns the gene SLC16A2 and Parkinsonism.