MGAT5 and cancer: Accordingly, the enhancement of branched N-glycans on T cells upon metabolic supplementation with glycans (GlcNAc-N-acetylglucosamine) was previously shown to suppress T-cell-mediated immune response in immune-mediated diseases,47 such as in IBD.16 Additionally, this glycan supplementation was associated with a reduction in Th1 and Th17 responses.47 In fact, Mgat5 KO mice exhibited an overall increased production of potent antitumor cytokines such as IFNγ and IL-17, alongside an increased infiltration of γδ T cells that overall resulted in cancer suppression.