MGAT5 and inflammatory bowel disease: This regulatory role on T cells imposed by the levels of branched N-glycans is in line with previous evidence showing that Mgat5 overexpression was associated with reduced Th1 responses.46 In fact, the high-mannose-enriched T-cell glycome observed in Mgat5 KO mice was already described to be associated with an increased activation of T cells and a hyperimmune response in active IBD,16 a glycophenotype that is lost in WT mice, fostering the transition from active inflammation, to dysplasia and cancer.