In this regard, it is interesting to speculate that galectin‐3 might mediate the effect of FBXW7 on TROP2 levels because galectin‐3 positively regulates TROP2 (TACSTD2) gene expression in colorectal cancer cells [25] and both galectin‐3 and TROP2 exhibited increased levels in the two FBXW7‐mutated EC cell lines in our study. This evidence concerns the gene TACSTD2 and colorectal cancer.