Several recent studies have implicated ICAM‐1 in the regulation of macrophage polarization.[28, 42, 43] In line with these studies, our findings suggest that the activation of Nlrp3+Icam1+ myeloid cells contributes to M1 polarization and exacerbated inflammation in the pathobiology of PA‐induced ALI. The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.