Similar to how neurons and muscle tissue utilize GLUT4 to sustain increased metabolic demands, our data suggest that pediatric gliomas, especially the H3 mutant high-grade gliomas, depend on glucose metabolism and may utilize GLUT4 to support the energetic demands of tumor growth, although a dependence on GLUT4 may be tumor microenvironment dependent. Here, SLC2A4 is linked to glioma.