Naive CD8 + T cells with high expression of LEF1 and TCF7 (TC1) were significantly decreased in COVID-19 liver (FDR = 1.45 × 10−9, OR = 0.629, Binomial GLMM), while cytotoxic effector/memory T cells (TC3), expressing IFNγ, CX3CR1, TGFBR3, GNLY, and GZMH, and the apoptotic naive T cell-like (TC4) population were both significantly increased in the COVID-19 liver (TC3, TC4: FDR = 1.69 × 10−4, 2.59 × 10−2; OR = 4.127,1.969, respectively, Binomial GLMM). Here, LEF1 is linked to COVID-19.