In the myeloid compartment, there were no differences in classical Kupffer cells (KCs) (MAC1) or inflammatory KCs (MAC3) (MAC1, MAC3: FDR = 0.231, 0.154; OR = 0.925, 0.873, respectively, Binomial GLMM), but an increased proportion of MAC2 cells was observed in COVID-19 (FDR = 1.86 × 10−2, OR = 1.182, Binomial GLMM), an intermediate phagocytic macrophage phenotype with lower expression of MARCO and CD164 but increased expression of phagocytic markers (C5AR1, CPVL, CD206). This evidence concerns the gene MARCO and COVID-19.