TGFB1 and Hepatic fibrosis: HEP Inf cells were identified as a dominant signaling hub for a TGFβ communications network comprising endothelial, cholangiocyte, and immune cells (Fig. 5e, Additional file 2: Fig. S7b), consistent with previous reports related to chronic immune reaction [72], and TGF-β implication in inflammation and liver fibrosis.