LYVE1 and COVID-19: Conversely, EC2s, typical liver sinusoidal endothelial cells (LSEC) with high lymphatic vessel endothelial hyaluronan receptor (LYVE1) expression, and EC8s with features of classical vascular endothelial cells and high anti-inflammatory gene C7 expression [55] were both significantly reduced in the COVID-19 samples (EC2, EC8: FDR = 7.10 × 10−11, 5.16 × 10−29; OR = 0.378,0.142, respectively, Binomial GLMM) (Fig. 3d).