Although PD-L1 blockade (αPD-L1) could not further fuel the anti-tumor capacity of NLRP4, we confirmed an outstanding tumor-suppressive capacity of NLRP4-eco, which was far more intensive than αPD-L1 reprogrammed TIME (αPD-L1-eco) (Fig. S2a). This evidence concerns the gene NLRP4 and neoplasm.