NLRP4 and Carcinoma, Lewis Lung: Firstly, neither NLRP4 overexpression (NLRP4-OE) nor knockdown (NLRP4-KD) in Lewis lung carcinoma (LLC) affected cell growth velocity proved by CCK-8 assay (Fig. 2a), and on the contrary, NLRP4-OE led to significant tumor shrinking in immunocompetent C57BL/6 mice (Fig. 2b, Fig. S2b), underpinning immune infiltration responsible for NLRP4-OE anti-tumor capacity.