The decrease in renal UMOD and Umod gene expression 8 and 12 weeks after Snx paralleled a decline in kidney function, indicated through increased serum creatinine (Fig. 7a), kidney injury (KIM-1-positivity) (Fig. 7b), tubular atrophy (Fig. 7c), glomerulosclerosis (Fig. 7d) and interstitial fibrosis (Fig. 7e). Here, UMOD is linked to glomerulosclerosis.