BMI1 and nasopharyngeal carcinoma: Interestingly, we found that BMI1 is positively involved in regulating stemness-related pathways in Head-and-neck Carcinoma (Fig. 5D), so we predicted that BMI1 may be a key downstream mRNA for circCENPM to augment the growth, metastasis, and stemness of NPC through the ceRNA mechanism.