Additionally, treatment with tick salivary biomolecules containing MET and p23 in the zebrafish model of AGS reduced M. marinum gut infection levels and risk of tuberculosis, presenting lower values of pro-inflammatory cytokines and mediators (tnfα, il1b, tlr2 and prkdc), combined with previously reported protective titers of anti-α-Gal IgM antibodies20. This evidence concerns the gene IL1B and tuberculosis.