In 2024, we celebrated the 30th anniversary of the discovery of nuclear factor erythroid 2-related factor 2 (NRF2)1 Over the years, investigations in this field have underscored the crucial roles of NRF2, a transcription factor that regulates cytoprotective genes to mitigate various pathologies relating to inflammatory, neurodegenerative, respiratory, and cardiovascular diseases. Here, NFE2L2 is linked to cardiovascular disorder.