Pharmacological inhibition of glycolysis with bromopyruvic acid directly modulates the inflammatory functions mediated by FLSs to reduce cartilage degeneration.51 Moreover, inhibiting lysine-specific demethylase 1 in osteoclast precursors52 or specifically deleting hexokinase 2 (HK2) in non-hematopoietic cells53 reduces arthritis severity and bone and cartilage damage by modulating glycolytic activities. This evidence concerns the gene HK2 and Arthritis.