In our RNA-seq analyses, we observed upregulation of numerous Hox genes in both Six2-ENLT1 and Six2-ENLT3 mutant kidneys (Supplementary Fig. 9f, i, j and Supplementary Data 3), largely resembling what was observed in Wilms tumors with ENL mutations19,20. Here, MLLT1 is linked to Nephroblastoma.