Similar to what we observed in the RNA-seq analysis of whole kidneys (Supplementary Fig. 9d, e), up and down DEGs in HEK293 cells expressing human ENLT1 and in ENL-mutant Wilms tumors were enriched in the sorted ENLT1 mutant nephron progenitors and their derived cells from E14.5 and/or E18.5 kidneys (Fig. 3e and Supplementary Fig. 10b). Here, MLLT1 is linked to Nephroblastoma.