In terms of emotional processing, vortioxetine reduced emotional blunting in a sample experiencing depression which had partially responded to SSRI medication (Fagiolini et al. 2021), indicating that the addition of 5-HT1A receptor agonism to serotonin reuptake inhibition could have a beneficial effect on both emotional processing and cognition, that neither mechanism would have alone. Here, HTR1A is linked to major depressive disorder.