NPM1 and cancer: Eight COSMIC fusions with known relevance to cancer biology including the hallmark fusions mentioned above were identified among most (6/9) of the cell lines and identified by at least two prediction methods with similar quantities of reads for each fusion, spanning two orders of magnitude (two reads for K562|BCR::ABL1 to 462 reads for KIJK|ALK::NPM1) (Fig. 4B).