As AXT914 rectified the altered Ca2+e-mediated Ca2+i responses associated with the Nuf mouse CaSR mutation (Leu723Gln) in vitro, we proceeded to an in vivo assessment of this calcilytic in Casr+/Nuf mice, which have hypocalcemia and reduced plasma PTH concentrations (Table 2). The gene discussed is CASR; the disease is Hypocalcemia.