GNA11 and autosomal dominant hypocalcemia: Autosomal dominant hypocalcemia (ADH) is a monogenic disorder of systemic calcium homeostasis consisting of two types: ADH1 (OMIM #601198), which is caused by germline gain-of-function mutations of the extracellular calcium-sensing receptor (CaSR) (1, 2); and ADH2 (OMIM #615361), which is due to germline gain-of-function mutations of G-protein subunit alpha-11 (Gα11) (3, 4, 5).