Microglia from the three other patients carried activating KRAS (p.A59G), PTPN11 (p.T73I), and TEK (p.R1099*) oncogenic variants previously described in cancer and sporadic venous malformations (Kim et al., 2016; Niihori et al., 2005; Soblet et al., 2013; Figure 3B and D). Here, PTPN11 is linked to cancer.