CBL and Alzheimer disease: Strikingly, half of these patients (six patients, 13% of AD patients in this series) carried recurrent P-SNV in the RING domain of CBL (Schnittger et al., 2012; Fernandes et al., 2010; Sargin et al., 2007; Dunbar et al., 2008; Bernard et al., 2014; Loh et al., 2009; Grand et al., 2009; Klampfl et al., 2013; Niemeyer et al., 2010; Javadi et al., 2013; Ogawa, 2019; Figure 3B–E).