SMAD3 and chronic myelogenous leukemia, BCR-ABL1 positive: Finally, two patients carried oncogenic variants in genes from the KEGG Chronic Myeloid Leukemia (CML) pathway, SMAD3 (p.R373C) Ku et al., 2007, and TP53 (pX261_splice) Bougeard et al., 2015 (Figure 3D and Figure 2—figure supplement 2).