SPI1 and Alzheimer disease: Of note, we did not observe microglia P-SNVs within genes reported to be associated with neurological disorders (Supplementary file 2) in patients (Supplementary file 3). P-SNV targeting genes of the classical RTK/MAPK pathway (Figure 3C) were detected in the PU.1+ samples from ~25% of the AD patients tested (p=0.0145 vs age-matched controls, Figure 3D, Figure 2—figure supplement 2).