RIT1 and RASopathy: RIT1 is a RAS GTPase, and somatic or germ-line GOF variants such as RIT1 F82L and RIT1 M90I, also enhance MAPK signaling in malignancies Gómez-Seguí et al., 2013 and RASopathies (Meyer Zum Büschenfelde et al., 2018; Aoki et al., 2013), respectively.