CASP1 and infection: Simultaneously, AjCASP-1 activity was significantly upregulated after AJ01 infection (S4B Fig), which could be inhibited by 25 μm of Z-YVAD-FMK (CASP-1-specific inhibitor) without reduce coelomocyte viability in the uninfected coelomocytes (S4C–S4D Fig).