SIRT1 and cancer: NAMPT and SIRT1 are overexpressed in several malignant tumor types, including colorectal, ovarian, breast, gastric, thyroid, and prostate cancers, as well as numerous malignant lymphomas, due to the increased requirement for energy metabolism (Wang et al. 2011; Bi et al. 2011; Huang et al. 2013; Venkateshaiah et al. 2013; Maldi et al. 2013; Shackelford et al. 2013; Zhou et al. 2018).