SIRT1 and cancer: Considering the importance of NAMPT signalling in cancer and the possible off-target effects due to inhibition of NAMPT, particularly in the brain, our in silico studies attempt to understand the possible interactions with the NAMPT and SIRT1 proteins by quercetin and some of its analogues having neuroprotective potential but not tested against the NAMPT mediated NAD+/SIRT1 pathway using Schrodinger Maestro software.