In a human cardiomyocyte cell line (a tumor cell line expressing only calcitonin receptor-like receptors and RAMP1), CGRP increased the cAMP level, calcium ion transients, nitric oxide formation, and phosphorylation of the extracellular signal-regulated kinases ERK1/2 (Clark et al. 2021). The gene discussed is CALCRL; the disease is neoplasm.