GCA-affected aorta tissues showed increased expression of CD90, FAP, PDPN, CD248 and PDGFB in the media compared with atherosclerotic aorta used as control tissue, whereas α-SMA, TGF-β and FGF21 expression in the media showed no significant differences (Fig. 3A, B, Supplementary Fig. S4C, available at Rheumatology online). The gene discussed is ACTA1; the disease is temporal arteritis.