Attenuated androgens have been administered in the past for STP 5 days before and 2–3 days post-event.6,18 Routine prophylactic treatment with C1-INH improves overall quality of life, including parameters related to anxiety.17 Preprocedural anxiety assessment, especially in patients with intense odontophobia possibly followed by pharmacological sedation, preferably through oral or nasal routes, may be essential in the management of HAE patients.20 This evidence concerns the gene SERPING1 and Anxiety.