It can promote tumor invasion, metastasis 27, and proliferation 28 by interacting with receptors (such as RAGE and TLRs), thereby activating downstream signaling pathways including NF-κB/IL-6 29, caspase-1 30, PI3K/AKT 31 and cyclin D1 32. The gene discussed is NFKB1; the disease is neoplasm.