LncRNA TP73-AS1 functions as an oncogene in HCC by promoting M2 macrophage infiltration via the miR-539/MMP-8/TGF-β1 signaling pathway 16 and regulates HCC cell proliferation through the miR-200a/HMGB1 pathway 17. Here, TGFB1 is linked to hepatocellular carcinoma.