Under the conditions for SMR analysis, we conducted cis-MR analysis on the dual-positive genes to further infer the relationships between PAH and T1DM, as well as PBC. Figure 10 shows that there are 21 genes exhibiting dual positivity between PAH and PBC, with PM20D1 and NUCKS1 being the most significant. Here, NUCKS1 is linked to pulmonary arterial hypertension.