sc-RNA seq and assignment into two types of NK cells confirmed that heatstroke and sepsis were associated with lower number of NK cells than that in the other two groups (Figure S6D-F), rather than affecting the relative abundance of CD56bri NK cells (NKG7+XCL1+) and CD56dim NK cells (NKG7+FGFBP2+) (Figure S6G). The gene discussed is XCL1; the disease is Sepsis.