The ratio of Treg cells to CD8+ T cells, a feature of T cell exhaustion, was higher among patients who died or showed nervous system dysfunction, acute heart failure or acute lung injury within 30 days after admission (Figure 3O), which was not observed in patients with sepsis (Figure S4M), possibly because the fact that the median time from symptom onset to assessment was 60 h in our study, whereas the immunosuppression that contributes to organ injury after sepsis appears to begin at least 3 days after admission 20, 21. This evidence concerns the gene CD8A and Sepsis.