Our previous studies have shown that PRF is rich in transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and other growth factors, which can accelerate the healing of pressure sore wounds in rats and skin wounds in diabetes mice by promoting cell proliferation 21, 22. This evidence concerns the gene VEGFA and diabetes mellitus.