NOS3 and ischemia: In the treatments applied in MIR, thrombus causing ischemia is formed with platelet aggregation occurring after plaque rupture, substances such as serotonin, thromboxane A2, and thrombin released from these platelets and endothelial nitric oxide synthase (eNOS)-mediated nitric oxide (NO)-mediated vasoconstriction in the lesion area and ischemia-induced oxygenation of the distal tissue may be further impaired 6,7.