MGMT and neoplasm: A final multivariate model including metabolically active tumor volume (P = .011), MGMT promoter methylation status (P = .314), age (P = .232), extent of resection at initial diagnosis (P = .824) and ECOG score (P = .865) confirmed the independent association of FC between tumor region and the visual network with overall survival (HR, 0.90; 95% CI, 0.82–0.99; P = .031; Table 3).