MGMT and neoplasm: Furthermore, FC between the metabolic active tumor regions and the DAN had an independent association with overall survival (HR, 0.90; 95% CI, 0.81–0.99; P = .033) in a multivariate model (Table 3) that excluded features correlated with connectivity (IDH, tumor type, tumor grade) but included other tumor-related variables such as the metabolically active tumor volume (P = .023) and MGMT promoter methylation status (P = .057), as well as common prognostic factors such as age (P = .215), extent of resection at initial diagnosis (P = .162), and ECOG score (P = .172).