Based on the global population and the estimated prevalence of hemophilia at birth [23], this number of reported people with hemophilia (257,146) represents approximately 22% of the expected number of people with hemophilia (1,184,000) worldwide (see formulas 1 and 2), including about 282,266 with FVIII or FIX activity levels < 1% of normal. This evidence concerns the gene F8 and hemophilia.