KL and schizophrenia: Our data from chronic SZ patients add to the dynamic relationship reported between schizophrenia and Klotho, with significantly lower as well as elevated levels observed in patients with schizophrenia being admitted to hospitals reporting acute exacerbation for their psychotic symptoms.29,30 As mentioned earlier, KL-VSHet+ also did not influence KL protein levels in controls, with slight evidence of heterozygosity-associated KL elevation in patients.