These phenomena indicate that the absence of TFEB in tumor largely attenuated the anticancer effect of GK, which was further demonstrated with the expression of PCNA observed by IHC, GK notably decreased the expression of PCNA in A549-luci mice, while this decrease was less pronounced in A549 TFEB-/--luci mice (Figure 9C-D). The gene discussed is PCNA; the disease is neoplasm.