To clarify the role of liver-infiltrating neutrophils in T-cell exhaustion and HCC progression induced by HCC exosomes, SB225002, the inhibitor of CXCR2 which is the major chemokine receptor of neutrophils, was used to block neutrophil infiltration (Figure 2A) 25, 26. This evidence concerns the gene CXCR2 and hepatocellular carcinoma.