In DEN/CCl4-induced HCC mice, we observed HCC exosome treatment did not affect the number of liver-infiltrating NK cells (Figure S12A), but induced NK cell functional exhaustion, as evidenced by the downregulation of TNF-α and the upregulation of PD-1 and TIGIT (Figure S12B-C). Here, TIGIT is linked to hepatocellular carcinoma.