Although there was no obvious influence on the number of liver-infiltrating T cells (Figure S1D-F), HCC exosomes significantly upregulated the expression of PD-1 and TIGIT and downregulated the expression of TNF-α on CD8+ T cells (Figure 1N-O) and CD4+ T cells (Figure S1G-H). This evidence concerns the gene CD4 and hepatocellular carcinoma.