Similar to SB225002 treatment, α-Ly6g treatment significantly impeded the protumor effect of HCC exosomes (Figure 2I-K), accompanied with the recovery of CD8+ T cells (Figure 2L, S2D) and CD4+ T cells (Figure S2E-F) from exhaustion induced by HCC exosomes. This evidence concerns the gene CD4 and hepatocellular carcinoma.