We found that HCC exosomes did not significantly influence the expression of CXCL chemokines (Figure S9A), but HCC exosome-reprogrammed neutrophils upregulated the expression of CXCL1, CXCL2, and CXCL8 in HCC cells, forming a positive feedback loop to recruit more neutrophils (Figure S9B). This evidence concerns the gene CXCL2 and hepatocellular carcinoma.