Moreover, assessment of the mitochondrial membrane potential (MMP) using JC-1 revealed fewer JC-1 aggregates in PRR11 knockdown RCC cells and more JC-1 aggregates in PRR11 overexpressing RCC cells, suggesting a reduced MMP upon PRR11 silencing (Figure 5F and Figure S7C-E). This evidence concerns the gene PRR11 and renal cell carcinoma.