FBXW7 and renal cell carcinoma: To further characterize the relationship between PRR11 and FBXW7, we quantified PRR11 and FBXW7 protein expression by IHC in 149 clinical RCC samples from the HKidE180Su02 cohort and found that there was a significant negative correlation between PRR11 and FBXW7 protein levels (Figure 3F).