To evaluate its function in ATC drug resistance, we examined correlations between the expression of 12 m5C regulators [NSUN2-7, TRDMT1 (writers); ALKBH1, TET2, ALKBH3 (erasers); YBX1 and ALYREF (readers)] and drug sensitivity in the Cancer Therapeutics Response Portal (CTRP). The gene discussed is TRDMT1; the disease is cancer.