TPO and thyroid gland undifferentiated (anaplastic) carcinoma: To further explore the physiological role of NSUN2 in MDR of ATC, we developed a spontaneous tumorigenic model of murine anaplastic thyroid carcinoma (mATC) with an Nsun2 knockout by crossing Nsun2flox/flox mice with TPO-cre;BrafV600E;Trp53 flox/flox mice (Figure 2M).