We performed a search on MEDLINE, EMBASE, and the Cochrane Library, using the following terms without time limits: ’’central nervous system”, “central nervous system involvement,” “acute myeloid leukemia’’,”myeloid sarcoma,” “intrathecal chemotherapy,” and “radiotherapy”, to evaluate the efficacy of different therapies for AML with CNS involvement, including studies for FLT3-mutated and FLT3-WT AML. The gene discussed is FLT3; the disease is acute myeloid leukemia.