SREBF1 and diabetes mellitus: Diabetes may also be caused by a decrease in the expression of sterol regulatory element binding protein 1 and its target genes, fatty acid synthase, stearoyl-CoA desaturase-1, and acetyl-CoA carboxylase α as well as a decrease in the levels of C/EBP homologous protein, Caspase12, and Caspase3 proteins (78).