Given the relatively small number of studies assessing family history, TRUS findings, smoking history, history of hypertension, history of dyslipidemia, and MRI findings, along with the lack of significant heterogeneity in BMI, resected prostate weight, and preoperative negative prostate biopsy, we only performed subgroup analyses for age, pre-PSA, pre-PSAD, baseline PV, preoperative treatment with 5αRIs, DRE findings, and history of diabetes (Table 2). The gene discussed is KLK3; the disease is diabetes mellitus.